Yasui H, Kiyoshima J, Hori T, Shida K
Yakult Central Institute for Microbiological Research and Department of Microbiology, 1796 Yaho, Kunitachi-shi, Tokyo 186-8650, Japan.
Clin Diagn Lab Immunol. 1999 Mar;6(2):186-92. doi: 10.1128/CDLI.6.2.186-192.1999.
Mice fed Bifidobacterium breve YIT4064 and immunized orally with influenza virus were more strongly protected against influenza virus infection of the lower respiratory tract than ones immunized with influenza virus only. The number of mice with enhanced anti-influenza virus immunoglobulin G (IgG) in serum upon oral administration of B. breve YIT4064 and oral immunization with influenza virus was significantly greater than that upon oral immunization with influenza virus only. These findings demonstrated that the oral administration of B. breve YIT4064 increased anti-influenza virus IgG antibodies in serum and protected against influenza virus infection. The oral administration of B. breve YIT4064 may enhance antigen-specific IgG against various pathogenic antigens taken orally and induce protection against various virus infections.
喂食短双歧杆菌YIT4064并经口用流感病毒免疫的小鼠，比仅用流感病毒免疫的小鼠更能有效抵御下呼吸道的流感病毒感染。经口给予短双歧杆菌YIT4064并经口用流感病毒免疫后，血清中抗流感病毒免疫球蛋白G（IgG）增强的小鼠数量显著多于仅经口用流感病毒免疫的小鼠。这些研究结果表明，经口给予短双歧杆菌YIT4064可增加血清中抗流感病毒IgG抗体，并抵御流感病毒感染。经口给予短双歧杆菌YIT4064可能会增强针对口服摄入的各种致病抗原的抗原特异性IgG，并诱导抵御各种病毒感染的能力。
