Yasui H, Kiyoshima J, Ushijima H
Yakult Central Institute for Microbiological Research and Department of Microbiology, Institute of Public Health, Tokyo, Japan.
J Infect Dis. 1995 Aug;172(2):403-9. doi: 10.1093/infdis/172.2.403.
Mouse pups born to and nursed by dams fed Bifidobacterium breve YIT4064 and immunized orally with rotavirus were more strongly protected against rotavirus-induced diarrhea than those born to and nursed by dams immunized with rotavirus only. The level of antirotavirus IgA in milk of dams fed B. breve YIT4064 and immunized orally with rotavirus was significantly higher than that of dams immunized with rotavirus only. The antirotavirus IgA level in feces of dams immunized orally with rotavirus was also increased by oral administration of B. breve YIT4064. These findings demonstrate that oral administration of B. breve YIT4064 enhanced antigen-specific IgA antibody in the mammary gland and in the intestine. Oral administration of B. breve YIT4064 may enhance antigen-specific IgA antibody against various pathogenic antigens taken orally and induce protection against infections in various mucosal tissues.
由喂食短双歧杆菌YIT4064并口服轮状病毒免疫的母鼠所生并由其哺乳的幼鼠，比仅由口服轮状病毒免疫的母鼠所生并由其哺乳的幼鼠，对轮状病毒诱导的腹泻具有更强的抵抗力。喂食短双歧杆菌YIT4064并口服轮状病毒免疫的母鼠乳汁中的抗轮状病毒IgA水平，显著高于仅口服轮状病毒免疫的母鼠。口服短双歧杆菌YIT4064也使口服轮状病毒免疫的母鼠粪便中的抗轮状病毒IgA水平升高。这些发现表明，口服短双歧杆菌YIT4064可增强乳腺和肠道中的抗原特异性IgA抗体。口服短双歧杆菌YIT4064可能增强针对口服摄入的各种致病抗原的抗原特异性IgA抗体，并诱导对各种黏膜组织感染的保护作用。
