Chauhan O, Godhwani J L, Khanna N K, Pendse V K
Department of Pharmacology and Experimental Therapeutics, Dr. Sampurnanand Medical College, Jodhpur, India.
Indian J Exp Biol. 1998 Oct;36(10):985-9.
Muktashukti bhasma (MSB), an Ayurvedic compound, consisting of pearl, Aloe vera and vinegar, inhibited acute and subacute inflammation in albino rats as induced by subplanter injection of carrageenan, histamine, 5-HT, nystatin and subcutaneous implant of cotton pellets. In all the test procedures the antiinflammatory response of 1000 mg/kg MSB was comparable to the response observed with 300 mg/kg acetylsalicylic acid (ASA). Oral premedication with MSB delayed castor oil-induced diarrhoea in rats, indicating its prostaglandin inhibitory activity. The antiinflammatory activity of the compound is attributed to its ability to cause inhibition of prostaglandins, histamine and 5-HT and also by stabilization of the lysosomal membranes. The antiinflammatory activity of MSB seems one third to half as potent as ASA.
穆克塔舒克提散（MSB）是一种阿育吠陀化合物，由珍珠、芦荟和醋组成，可抑制由足跖注射角叉菜胶、组胺、5-羟色胺、制霉菌素以及皮下植入棉球诱导的白化大鼠急性和亚急性炎症。在所有测试程序中，1000毫克/千克MSB的抗炎反应与300毫克/千克乙酰水杨酸（ASA）观察到的反应相当。用MSB进行口服预处理可延迟蓖麻油诱导的大鼠腹泻，表明其具有前列腺素抑制活性。该化合物的抗炎活性归因于其抑制前列腺素、组胺和5-羟色胺的能力，以及稳定溶酶体膜的能力。MSB的抗炎活性似乎是ASA的三分之一到二分之一。
