常春藤在大鼠中的急性和慢性抗炎作用。

Acute and chronic antiinflammatory effects of Hedera colchica in rats.

作者信息

Gepdiremen Akçahan, Mshvildadze Vakhtang, Süleyman Halis, Elias Riad

机构信息

Department of Pharmacology, Atatürk University, Medical Faculty, TR-25240 Erzurum, Turkey.

出版信息

J Ethnopharmacol. 2004 Sep;94(1):191-5. doi: 10.1016/j.jep.2004.06.001.

DOI:10.1016/j.jep.2004.06.001

PMID:15261982

Abstract

Hedera helix and Hedera colchica are the members of Araliaceae family. In the present study, we tested the possible antiinflammatory effects of crude (CSE) and purified (SPE) extracts of Hedera colchica in carrageenan- and cotton pellet-induced acute and chronic inflammation models in rats. Both CSE and SPE of Hedera colchica were found to have antiinflammatory effects. The most potent drug was found as indomethacin (90%) in the 4 h measurements, while SPE (83%) and CSE (55%) of Hedera colchica in 100 mg/kg doses were found to have quite potent effects in acute phase of inflammation, in respect to control values. For testing chronic antiinflammatory (antiproliferative) effects, cotton pellet granuloma test was conducted. SPE was found as the most potent drug in chronic phase of inflammation with an effect of 64.32%. Indomethacin was found more potent than the CSE of Hedera colchica, and potency was found as 61.2 and 58%, respectively.

摘要

常春藤和科西嘉常春藤是五加科植物。在本研究中，我们在角叉菜胶和棉球诱导的大鼠急慢性炎症模型中测试了科西嘉常春藤粗提物（CSE）和纯化提取物（SPE）可能的抗炎作用。发现科西嘉常春藤的CSE和SPE均具有抗炎作用。在4小时的测量中，最有效的药物是吲哚美辛（90%），而100mg/kg剂量的科西嘉常春藤SPE（83%）和CSE（55%）在炎症急性期相对于对照值具有相当强的作用。为了测试慢性抗炎（抗增殖）作用，进行了棉球肉芽肿试验。发现SPE在炎症慢性期是最有效的药物，作用率为64.32%。发现吲哚美辛比科西嘉常春藤的CSE更有效，效力分别为61.2%和58%。