Egan J F, O'Leary B, Lewis M J, Mulcahy F, Sheehy N, Hasegawa H, Fitzpatrick F, O'Connor J J, O'Riordan J, Hall W W
Department of Medical Microbiology, University College Dublin, Belfield, Ireland.
AIDS Res Hum Retroviruses. 1999 May 20;15(8):699-705. doi: 10.1089/088922299310782.
Serological and molecular analyses of a cohort of HIV-1-infected intravenous drug abusers (IVDAs) (n = 103) in Dublin, Ireland have demonstrated that 15 of 103 (14.6%) were infected with HTLV-II, which is the highest infection rate yet recorded for any European country. Restriction fragment length polymorphism (RFLP) analysis of the env region of the provirus demonstrated that the infection involved only the HTLV-IIa subtype; the HTLV-IIb subtype was not detected. Phylogenetic analysis of the nucleotide sequences of the long terminal repeat (LTR) confirmed infection with the HTLV-IIa subtype, and demonstrated that the viruses clustered closely with HTLV-IIa isolates from North American IVDAs. Previous observations that IVDAs in southern Europe, specifically Spain and Italy, appear to be infected predominantly with the HTLV-IIb subtype, along with the present report and evidence that IVDAs in Sweden are infected with the HTLV-IIa subtype, suggest different origins of HTLV-II infection in Europe.
对爱尔兰都柏林一组103名感染HIV-1的静脉注射吸毒者（IVDAs）进行的血清学和分子分析表明，103人中有15人（14.6%）感染了HTLV-II，这是欧洲任何国家迄今记录的最高感染率。对前病毒env区域的限制性片段长度多态性（RFLP）分析表明，感染仅涉及HTLV-IIa亚型；未检测到HTLV-IIb亚型。对长末端重复序列（LTR）核苷酸序列的系统发育分析证实感染了HTLV-IIa亚型，并表明这些病毒与来自北美IVDAs的HTLV-IIa分离株密切聚集。先前的观察表明，南欧的IVDAs，特别是西班牙和意大利的IVDAs，似乎主要感染HTLV-IIb亚型，结合本报告以及瑞典IVDAs感染HTLV-IIa亚型的证据，表明欧洲HTLV-II感染的起源不同。
