Tee E S, Kandiah M, Awin N, Chong S M, Satgunasingam N, Kamarudin L, Milani S, Dugdale A E, Viteri F E
Division of Human Nutrition, Institute for Medical Research, Ministry of Health, Kuala Lumpur, Malaysia.
Am J Clin Nutr. 1999 Jun;69(6):1249-56. doi: 10.1093/ajcn/69.6.1249.
Iron deficiency and its consequent anemia constitute the commonest micronutrient deficiency in the world.
We investigated whether long-term, weekly iron-folate supplements administered at school would improve hemoglobin and ferritin concentrations in adolescent girls, including those with mild-to-moderate anemia and hemoglobin concentrations indicating borderline anemia.
Subjects were 266 girls with hemoglobin concentrations of 80-119.9 g/L (group A) and 358 girls with hemoglobin concentrations of 120-130 g/L (group B) who were otherwise healthy. Two hundred sixty-six girls in group A and 268 girls in group B were randomly assigned to receive either 60 or 120 mg Fe plus 3.5 mg folic acid weekly for 22 wk. Ninety of the girls in group B were randomly assigned to receive only 5 mg folic acid weekly. Capillary hemoglobin and plasma ferritin were measured at baseline and after 12 and 22 wk of supplementation.
By the end of the study, 2% of the girls had dropped out and > 96% had taken > or = 20 of the 22 tablets; side effects were minimal. Mean plasma ferritin increased significantly in all iron-supplemented groups, independently of initial hemoglobin values and iron doses. Ferritin concentrations decreased in the girls supplemented with folic acid only. As expected, hemoglobin responses to iron were higher in group A than in group B and increases were positively correlated with initial plasma ferritin. Hemoglobin failed to respond to folate supplementation if initial plasma ferritin concentrations were low. Mean hemoglobin increased significantly and consistently in relation to the length of treatment.
Long-term, weekly iron-folate supplementation was found to be a practical, safe, effective, and inexpensive method for improving iron nutrition in adolescent schoolgirls.
缺铁及其所致贫血是全球最常见的微量营养素缺乏症。
我们调查了在学校每周长期补充铁 - 叶酸是否会改善青春期女孩的血红蛋白和铁蛋白浓度，包括那些患有轻度至中度贫血以及血红蛋白浓度表明接近贫血临界值的女孩。
研究对象为266名血红蛋白浓度为80 - 119.9 g/L的女孩（A组）和358名血红蛋白浓度为120 - 130 g/L的女孩（B组），她们在其他方面均健康。A组的266名女孩和B组的268名女孩被随机分配，每周接受60毫克或120毫克铁加3.5毫克叶酸，持续22周。B组的90名女孩被随机分配仅每周接受5毫克叶酸。在基线时以及补充12周和22周后测量毛细血管血红蛋白和血浆铁蛋白。
到研究结束时，2%的女孩退出，超过96%的女孩服用了22片药片中的20片及以上；副作用极小。所有补充铁剂的组中，平均血浆铁蛋白显著增加，与初始血红蛋白值和铁剂量无关。仅补充叶酸的女孩中铁蛋白浓度下降。正如预期的那样，A组血红蛋白对铁的反应高于B组，且增加量与初始血浆铁蛋白呈正相关。如果初始血浆铁蛋白浓度低，血红蛋白对叶酸补充无反应。平均血红蛋白随着治疗时间的延长显著且持续增加。
长期每周补充铁 - 叶酸被发现是改善青春期女学生铁营养的一种实用、安全、有效且廉价的方法。
