Babcock D A, Narver E L, Dement W C, Mitler M M
Pharmacol Biochem Behav. 1976 Dec;5(6):599-602. doi: 10.1016/0091-3057(76)90298-7.
Four narcoleptic dogs with cataplexy were given trials with the serotonin uptake blockers imipramine and chlorimipramine (known to be effective in treating cataplexy in humans). An even more selective serotonin uptake blocker, fluoxetine, was also tested. Injections of placebo, test compound, and placebo were given respectively on 3 successive days. Anticataplectic effects were measured approximately 30 min, 3 hr, and 6 hr postinjection by recording elapsed time and number of cataplectic episodes during the dogs' attempts to eat ten pieces of a desired food presented in a standard fashion. Imipramine (1 mg/kg) and fluoxetine (1.5 and 3.0 mg/kg)significantly improved performance, while chlorimipramine (0.5-5 mg/kg) had no clear effect. Data were not totally consistent with the notion that serotonin uptake blockers improve cataplexy in dogs, since chlorimipramine was not effective in these animals.
对四只患有猝倒症的发作性睡病犬进行了5-羟色胺摄取阻滞剂丙咪嗪和氯米帕明（已知对治疗人类猝倒症有效）的试验。还测试了一种选择性更强的5-羟色胺摄取阻滞剂氟西汀。在连续3天分别注射安慰剂、测试化合物和安慰剂。通过记录犬以标准方式尝试吃十块喜欢的食物时的发作时间和猝倒发作次数，在注射后约30分钟、3小时和6小时测量抗猝倒作用。丙咪嗪（1毫克/千克）和氟西汀（1.5和3.0毫克/千克）显著改善了表现，而氯米帕明（0.5 - 5毫克/千克）没有明显效果。数据并不完全支持5-羟色胺摄取阻滞剂可改善犬猝倒症这一观点，因为氯米帕明对这些动物无效。
