Dencker S J, Bake B
Acta Psychiatr Scand. 1976 Jul;54(1):74-8. doi: 10.1111/j.1600-0447.1976.tb00095.x.
Three age- and sex-matched groups of 10 patients were treated intravenously with imipramine, chlorimipramine, and imipramine-N-oxide respectively, in increasing doses from 25 mg to 150-175 mg given as single daily infusions during 1 hour. No systemic changes of heart frequency and blood pressure were found during the infusions in spite of the high dosage of tricyclic antidepressants given such a short period as 1 hour. The patients were examined regarding orthostatic reactions as well as ECG changes before, after 4-5 infusions and after 8-10 infusions. There were more orthostatic abnormalities and ECG changes in the patients treated with imipramine than in those treated with imipramine-N-oxide and there were practically no changes in the chlorimipramine group. However, no statistically significant orthostatic changes were found.
将三组各10名年龄和性别匹配的患者分别静脉注射丙咪嗪、氯丙咪嗪和丙咪嗪 - N - 氧化物，剂量从25毫克开始逐渐增加至150 - 175毫克，每天单次输注1小时。尽管在如此短的1小时内给予了高剂量的三环类抗抑郁药，但在输注过程中未发现心率和血压的全身性变化。在4 - 5次输注前、后以及8 - 10次输注后，对患者进行了体位性反应和心电图变化检查。接受丙咪嗪治疗的患者比接受丙咪嗪 - N - 氧化物治疗的患者出现更多的体位性异常和心电图变化，而氯丙咪嗪组实际上没有变化。然而，未发现具有统计学意义的体位性变化。
