Pereira H S, Rebello M A
Carlos Chagas Filho Institute of Biophysics, Department of Virology, Federal University of Rio de Janeiro, Brazil.
Acta Virol. 1998 Dec;42(6):383-8.
The antibiotic cerulenin, an inhibitor of lipid synthesis, was shown to suppress Mayaro virus replication in Aedes albopictus cells at non-cytotoxic doses. Cerulenin blocked the incorporation of [3H]glycerol into lipids when present at any time post infection (p.i.). Cerulenin added at the beginning of infection inhibited the synthesis of virus proteins. However, when this antibiotic was added at later stages of infection, it had only a mild effect on the virus protein synthesis. The possibility that cerulenin acts by blocking an initial step in the Mayaro virus replication after virus entry and before late viral translation is discussed.
抗生素浅蓝菌素是一种脂质合成抑制剂，已证明它在非细胞毒性剂量下可抑制白纹伊蚊细胞中的马亚罗病毒复制。在感染后（p.i.）的任何时间存在时，浅蓝菌素都会阻止[3H]甘油掺入脂质中。在感染开始时添加浅蓝菌素可抑制病毒蛋白的合成。然而，当在感染后期添加这种抗生素时，它对病毒蛋白合成只有轻微影响。本文讨论了浅蓝菌素通过在病毒进入后和晚期病毒翻译之前阻断马亚罗病毒复制的初始步骤而起作用的可能性。
