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主动脉同种异体移植物在复杂气管支气管树损伤重建中的应用。

Use of the aortic homograft in the reconstruction of complex tracheobronchial tree injuries.

作者信息

Chahine A A, Tam V, Ricketts R R

机构信息

Division of Pediatric Surgery, Emory University and Egleston Children's Hospital, Atlanta, GA, USA.

出版信息

J Pediatr Surg. 1999 May;34(5):891-4. doi: 10.1016/s0022-3468(99)90393-7.

Abstract

BACKGROUND/PURPOSE: The repair of complex tracheobronchial tree injuries often is associated with complications including stenosis and excessive granulation tissue formation. Patch reconstruction using pericardium or synthetic material decreases the incidence of stenosis. The authors report on the use of the ascending aorta cryopreserved homograft in reconstructing the tracheobronchial tree of three children.

RESULTS

A 10 year old had a through-and-through gun shot wound to the left main stem bronchus with cartilaginous loss. A 12 year old double lung transplant recipient had a breakdown of one bronchial anastomosis after stent placement. A 1 year old had an acquired tracheoesophageal fistula secondary to a long standing foreign body. In all three patients, the aortic patches were secured with interrupted sutures. All three had uneventful recoveries, and postoperative bronchoscopy showed the patches to be completely covered with epithelium without stenosis or granulation tissue.

CONCLUSIONS

This is the first report of the use of the cryopreserved ascending aorta homograft in the reconstruction of the tracheobronchial tree. The homograft is strong yet malleable. It gets completely covered with epithelium and results in no stenosis because of the lack of tension. These characteristics make it an attractive alternative for the patch reconstruction of complex tracheobronchial tree injuries.

摘要

背景/目的:复杂气管支气管树损伤的修复常伴有包括狭窄和过度肉芽组织形成在内的并发症。使用心包或合成材料进行补片重建可降低狭窄的发生率。作者报告了使用升主动脉冷冻保存同种异体移植物重建三名儿童气管支气管树的情况。

结果

一名10岁儿童左主支气管遭受贯通性枪伤,软骨缺损。一名12岁双肺移植受者在置入支架后一个支气管吻合口破裂。一名1岁儿童因长期异物存留继发获得性气管食管瘘。在所有三名患者中,主动脉补片均用间断缝线固定。三人恢复均顺利,术后支气管镜检查显示补片完全被上皮覆盖,无狭窄或肉芽组织。

结论

这是关于使用冷冻保存的升主动脉同种异体移植物重建气管支气管树的首次报告。同种异体移植物坚固且可塑形。它完全被上皮覆盖,且由于没有张力而不会导致狭窄。这些特性使其成为复杂气管支气管树损伤补片重建的有吸引力的替代方法。

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