单个菌落中同时存在耐甲氧西林金黄色葡萄球菌和甲氧西林敏感金黄色葡萄球菌导致耐甲氧西林金黄色葡萄球菌误识别。

Occurrence of methicillin-resistant and -susceptible Staphylococcus aureus within a single colony contributing to MRSA mis-identification.

作者信息

Falcao M H L, Texeira L A, Ferreira-Carvalho B T, Borges-Neto A A, Figueiredo A M S

机构信息

Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Prof. Paulo de GÖes, Laboratorio de Biologia Molecular de Bacterias, Cidade Universitaria, CCS Bloco I, 21941.590, Rio de Janeiro, RJ, Brazil.

出版信息

J Med Microbiol. 1999 Jun;48(6):515-521. doi: 10.1099/00222615-48-6-515.

DOI:10.1099/00222615-48-6-515

PMID:10359299

Abstract

Many methods have been described for the detection of methicillin-resistant Staphylococcus aureus (MRSA), but the homogeneous or heterogeneous expression of methicillin resistance affects the reliability of those methods. This study demonstrates that close association between methicillin-susceptible S. aureus (MSSA) and MRSA strains in the host colonisation site can present additional problems for the detection of MRSA in clinical laboratories, which may contribute to failure in the control of MRSA infection in hospital. Worse, this association may also account for the emergence of MRSA during antibiotic therapy.

摘要

已经描述了许多检测耐甲氧西林金黄色葡萄球菌（MRSA）的方法，但甲氧西林耐药性的均匀或异质表达会影响这些方法的可靠性。本研究表明，在宿主定植部位，甲氧西林敏感金黄色葡萄球菌（MSSA）与MRSA菌株之间的密切关联可能给临床实验室检测MRSA带来额外问题，这可能导致医院中MRSA感染控制失败。更糟糕的是，这种关联也可能是抗生素治疗期间MRSA出现的原因。