Oshika T, Klyce S D, Applegate R A, Howland H C
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Invest Ophthalmol Vis Sci. 1999 Jun;40(7):1351-5.
To investigate whether corneal wavefront aberrations vary with aging.
One hundred two eyes of 102 normal subjects were evaluated with videokeratography. The data were decomposed using Taylor and Zernike polynomials to calculate the monochromatic aberrations of the cornea for both small (3-mm) and large (7-mm) pupils.
For a 3-mm pupil, the amount of total aberrations (Spearman rank correlation coefficient r(s) = 0.145; P = 0.103) and spherical-like aberrations (r(s) = -0.068; P = 0.448) did not change with aging, whereas comalike aberrations exhibited a weak but statistically significant correlation with age (r(s) = 0.256; P = 0.004). For a 7-mm pupil, total aberrations (r(s) = 0.552; P < 0.001) and comalike aberrations (r(s) = 0.561; P < 0.001) significantly increased with aging, but spherical-like aberrations showed no age-related changes (r(s) = 0.124; P = 0.166). Simulated pupillary dilation from 3 mm to 7 mm caused a 38.0+/-28.5-fold increase in the total aberrations, and the extent of increases significantly correlated with age (r(s) = 0.354; P < 0.001). Pupillary dilation influenced the comalike aberrations more in the older subjects than in the younger subjects (r(s) = 0.243; P = 0.006), but such age dependence was not found for spherical-like aberrations (r(s) = 0.141; P = 0.115).
Comalike aberrations of the cornea correlate with age, implying that the corneas become less symmetrical along with aging. Spherical-like aberrations do not vary significantly with aging. Pupillary dilation markedly increases wavefront aberrations, and those effects are more prominent in older subjects than in younger subjects.
研究角膜波前像差是否随年龄增长而变化。
用角膜地形图仪对102名正常受试者的102只眼进行评估。使用泰勒多项式和泽尼克多项式对数据进行分解，以计算小瞳孔（3毫米）和大瞳孔（7毫米）情况下角膜的单色像差。
对于3毫米的瞳孔，总像差量（斯皮尔曼等级相关系数r(s)=0.145；P=0.103）和类球面像差（r(s)= -0.068；P=0.448）不随年龄变化，而类慧差与年龄呈现弱但具有统计学意义的相关性（r(s)=0.256；P=0.004）。对于7毫米的瞳孔，总像差（r(s)=0.552；P<0.001）和类慧差（r(s)=0.561；P<0.001）随年龄显著增加，但类球面像差未显示出与年龄相关的变化（r(s)=0.124；P=0.166）。模拟瞳孔从3毫米扩张到7毫米导致总像差增加38.0±28.5倍，且增加程度与年龄显著相关（r(s)=0.354；P<0.001）。瞳孔扩张对老年受试者类慧差的影响比对年轻受试者更大（r(s)=0.243；P=0.006），但类球面像差未发现这种年龄依赖性（r(s)=0.141；P=0.115）。
角膜类慧差与年龄相关，这意味着随着年龄增长角膜对称性降低。类球面像差不随年龄显著变化。瞳孔扩张显著增加波前像差，且这些影响在老年受试者中比在年轻受试者中更明显。
