Aier Eye Hospital of Wuhan University (Wuhan Aier Eye Hospital), Wuhan, Hubei Province, China.
New Bund Medical and Surgical Center, Sino United Health Clinics, Shanghai, China.
BMC Ophthalmol. 2023 Jul 12;23(1):313. doi: 10.1186/s12886-023-03067-0.
To observe the distribution characteristics of corneal higher-order aberrations (HOAs) in cataract patients, and analyze the relationship of HOAs with patients' age and ocular biometric parameters.
This retrospective study reviews the patients with cataract in Wuhan Aier Eye Department from January to August 2022. Root mean square (RMS) of the total HOA (tHOA), spherical aberration (SA), coma and trefoil aberration of the anterior cornea at central 4 and 6 mm optic zone were measured by the Wavefront Aberrometer (OPD-Scan III; Nidek Inc, Tokyo, Japan). The biometric parameters including axial length (AL), keratometry (K), central corneal thickness (CCT) and lens thickness (LT) were measured by swept-source coherence laser interferometry (OA-2000; TOMEY Corp, Aichi, Japan). Subgroup analyses and multiple linear regression analyses were used to determine whether HOAs were associated with age and ocular biometric parameters.
A total of 976 patients (976 eyes) were included, averagely aged 65 years. At central 4 and 6 mm optic zone, the mean RMS of tHOA were respectively 0.20 and 0.65 μm, the SA were 0.06 and 0.30 μm, the coma aberration were 0.11 and 0.35 μm, and the trefoil aberration were 0.12 and 0.30 μm. The tHOA decreased with age until 60 years and then started to increase afterwards. The tHOA, coma and trefoil aberration increased with corneal astigmatism. The tHOA, SA, and coma aberration differ among different AL groups, and emmetropes had the smallest tHOA, SA, and coma aberration.
With increasing age, the value of tHOA decrease first and started increasing at 60 years. The trends of corneal HOAs are consistent with corneal low-order aberrations. The values of tHOA, SA and coma aberration were the smallest in emmetropic eyes.
观察白内障患者角膜高阶像差（HOAs）的分布特征，并分析HOAs与患者年龄和眼部生物测量参数的关系。
本回顾性研究纳入了 2022 年 1 月至 8 月期间在武汉爱尔眼科医院就诊的白内障患者。使用眼前节像差分析系统（OPD-Scan III；尼德克公司，日本东京）测量中央 4mm 和 6mm 光区角膜前表面总像差（tHOA）、球差、彗差和三叶草像差的均方根（RMS）值。采用扫频源相干光断层扫描仪（OA-2000；拓普康公司，日本爱知县）测量眼轴长度（AL）、角膜曲率（K）、中央角膜厚度（CCT）和晶状体厚度（LT）等生物测量参数。采用分组分析和多元线性回归分析来确定 HOAs 是否与年龄和眼部生物测量参数相关。
共纳入 976 例（976 只眼）患者，平均年龄为 65 岁。在中央 4mm 和 6mm 光区，tHOA 的平均 RMS 值分别为 0.20μm 和 0.65μm，球差分别为 0.06μm 和 0.30μm，彗差分别为 0.11μm 和 0.35μm，三叶草像差分别为 0.12μm 和 0.30μm。tHOA 随年龄增长先降低至 60 岁，随后开始升高。tHOA、彗差和三叶草像差随角膜散光增加而增加。tHOA、球差和彗差在不同 AL 组之间存在差异，正视眼的 tHOA、球差和彗差最小。
随着年龄的增长，tHOA 值先降低，60 岁后开始升高。角膜 HOAs 的变化趋势与角膜低阶像差一致。正视眼中的 tHOA、球差和彗差最小。
