Oshika Tetsuro, Okamoto Chikako, Samejima Tomokazu, Tokunaga Tadatoshi, Miyata Kazunori
Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Ophthalmology. 2006 Oct;113(10):1807-12. doi: 10.1016/j.ophtha.2006.03.061. Epub 2006 Jul 31.
To investigate the relation between contrast sensitivity function and ocular higher-order wavefront aberrations in normal human eyes.
Prospective observational case series.
Three hundred seven eyes of 161 normal subjects, ranging in age from 15 to 60 years (30.9+/-8.0 [mean +/- standard deviation]).
Ocular higher-order aberrations were measured for a 4-mm pupil using the Hartmann-Shack wavefront analyzer. The root-mean-square of the third- and fourth-order Zernike coefficients was used to represent comalike and spherical-like aberrations, respectively. We measured contrast sensitivity, low-contrast visual acuity (VA), and letter contrast sensitivity. From the contrast sensitivity data, the area under the log contrast sensitivity function (AULCSF) was calculated. Pupil diameter in a photopic condition was recorded using a digital camera.
Multiple linear regression analysis revealed that comalike aberration (P = 0.002) was significantly associated with AULCSF, but spherical-like aberration (P = 0.200), age (P = 0.185), and photopic pupil diameter (P=0.252) were not. Comalike aberration showed a significant correlation with low-contrast VA (P<0.001), but spherical-like aberration (P = 0.293), age (P = 0.266), and pupil diameter (P = 0.756) did not. Comalike aberration was found to be significantly associated with letter contrast sensitivity (P<0.001), but spherical-like aberration (P=0.082), age (P = 0.370), and pupil diameter (P = 0.160) were not.
In normal human eyes, comalike aberration of the eye significantly influences contrast sensitivity function.
研究正常人类眼睛中对比敏感度函数与眼高阶波前像差之间的关系。
前瞻性观察病例系列。
161名正常受试者的307只眼睛，年龄范围为15至60岁（30.9±8.0[平均值±标准差]）。
使用Hartmann-Shack波前分析仪测量4毫米瞳孔的眼高阶像差。分别用三阶和四阶泽尼克系数的均方根来表示类似慧差和类似球差的像差。我们测量了对比敏感度、低对比度视力（VA）和字母对比敏感度。根据对比敏感度数据，计算对数对比敏感度函数下的面积（AULCSF）。使用数码相机记录明视条件下的瞳孔直径。
多元线性回归分析显示，类似慧差（P = 0.002）与AULCSF显著相关，但类似球差（P = 0.200）、年龄（P = 0.185）和明视瞳孔直径（P = 0.252）则不然。类似慧差与低对比度VA显著相关（P<0.001），但类似球差（P = 0.293）、年龄（P = 0.266）和瞳孔直径（P = 0.756）则不然。发现类似慧差与字母对比敏感度显著相关（P<0.001），但类似球差（P = 0.082）、年龄（P = 0.370）和瞳孔直径（P = 0.160）则不然。
在正常人类眼睛中，眼睛的类似慧差显著影响对比敏感度函数。
