Nagle C A, Rosner J M
Neuroendocrinology. 1976;22(1):89-96. doi: 10.1159/000122614.
In four-day cycling rats studied during the estrous cycle, the levels of circulating norepinephrine (NE) showed a sharp rise concomitant with the LH surge in the afternoon of proestrus. Following the peak, plasma NE fell rapidly to the minimum value by the morning of estrus. The administration of progesterone to ovariectomized estrogen-primed rats resulted in a surge in plasma NE levels 4 h after progesterone treatment. The maximal levels attained were 3-fold greater than baseline values, falling rapidly to reach basal values 8 h after the administration of progesterone. The amine levels remained unaffected 12-20 h later. The LH values attained a maximum 8 h after the injection of progesterone. In rats treated with estradiol benzoate (EB) followed by 0.1 ml of oil instead of progesterone, neither the NE nor the LH peak were observed. These findings are discussed with respect to the significance of increased amounts of plasma NE related to the LH surge.
在发情周期中进行研究的为期四天的骑行大鼠中，循环去甲肾上腺素（NE）水平在发情前期下午与促黄体生成素（LH）高峰同时急剧上升。达到峰值后，血浆NE在发情期早晨迅速降至最低值。对切除卵巢并用雌激素预处理的大鼠给予孕酮后，孕酮处理4小时后血浆NE水平激增。达到的最高水平比基线值高3倍，在给予孕酮8小时后迅速下降至基础值。12 - 20小时后胺水平未受影响。注射孕酮8小时后LH值达到最大值。在用苯甲酸雌二醇（EB）处理后再注射0.1 ml油而非孕酮的大鼠中，未观察到NE或LH峰值。就与LH高峰相关的血浆NE量增加的意义对这些发现进行了讨论。
