Lakhin R E, Belozerova L A, Maksimets V A, Romanov D M
Anesteziol Reanimatol. 1999 Mar-Apr(2):55-8.
Effects of hyperbaric oxygenation, bemitil, and solcoseryl used in preoperative treatment of patients with hepatic failure on the oxidant-antioxidant system are studied. Lipid peroxidation (LPO) was assessed from changes in the levels of malonic dialdehyde and diene conjugate and the antioxidant system from the number of SH-groups. Hyperbaric oxygenation led to activation of LPO processes. Bemitil decreased the intensity of LPO by extending the potentialities of the antioxidant system. Antioxidant properties of solcoseryl were not realized through the thiol buffer of the antioxidant system. Only a course of treatment with this drug brings about a stable effect.
研究了高压氧、贝米替尔和素高捷疗用于肝功能衰竭患者术前治疗时对氧化-抗氧化系统的影响。通过丙二醛和二烯共轭物水平的变化评估脂质过氧化（LPO），通过SH基团数量评估抗氧化系统。高压氧导致LPO过程激活。贝米替尔通过扩展抗氧化系统的潜能降低LPO强度。素高捷疗的抗氧化特性未通过抗氧化系统的硫醇缓冲实现。只有该药物的一个疗程才能产生稳定效果。
