Nikolaeva E E, Stepanenko E M, Chubukhchiev G B
Anesteziol Reanimatol. 1991 Jul-Aug(4):67-8.
The effect of hyperbaric oxygenation (HBO) used in the pre- and postoperative periods on the content of lipid peroxidation (LPO) products in the plasma and erythrocyte membranes and on the physiological antioxidant activity has been assessed in patients with lung cancer. It has been shown that hypoxia in patients with lung cancer is accompanied by LPO activation and decreased antioxidant protection. Surgery increases hypoxia and further activates LPO. HBO has a positive effect on LPO processes manifested in a decrease of secondary LPO products content and mobilization of antioxidant activity, i.e. protects the cellular membrane from hypoxia-induced damages, promotes a 1.5-fold reduction in the incidence of postoperative complications, and enhances the efficacy of surgical treatment of patients with lung cancer.
对肺癌患者术前和术后使用高压氧疗（HBO）对血浆和红细胞膜中脂质过氧化（LPO）产物含量以及生理抗氧化活性的影响进行了评估。结果表明，肺癌患者的缺氧伴随着LPO激活和抗氧化保护作用降低。手术会加重缺氧并进一步激活LPO。HBO对LPO过程具有积极影响，表现为二级LPO产物含量降低和抗氧化活性动员，即保护细胞膜免受缺氧诱导的损伤，使术后并发症发生率降低1.5倍，并提高肺癌患者手术治疗的疗效。
