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[大鼠高压氧治疗过程中的铜蓝蛋白-转铁蛋白抗氧化系统]

[The ceruloplasmin-transferrin antioxidant system during hyperbaric oxygenation in rats].

作者信息

Shinkarenko L I, Kozlov A V, Gol'dshteĭn N I, Azizova O A, Vladimirov Iu A

出版信息

Biull Eksp Biol Med. 1987 Sep;104(9):281-3.

PMID:3663907
Abstract

Antioxidant system ceruloplasmin-transferrin (Cp-Tr) and malonic dialdehyde (MDA) concentration changes were studied in the rat serum after the exposure to hyperbaric oxygenation (HBO) at 4 atm for 25 min. 5 sessions of HBO led to an increase in serum MDA concentration. 5 HBO sessions were followed by the activation of Cp-Tr system. Afterwards MDA concentration began to decrease and by the 9th session even reached the initial levels. It is suggested that antioxidant system Cp-Tr takes part in the protection of the organism from toxic oxygen action.

摘要

研究了大鼠血清中抗氧化系统铜蓝蛋白 - 转铁蛋白(Cp-Tr)和丙二醛(MDA)浓度在4个大气压下暴露于高压氧(HBO)25分钟后的变化。5次HBO治疗导致血清MDA浓度升高。5次HBO治疗后Cp-Tr系统被激活。之后MDA浓度开始下降,到第9次治疗时甚至达到初始水平。提示抗氧化系统Cp-Tr参与保护机体免受有毒氧作用。

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