Asymmetric synthesis of L-azetidine-2-carboxylic acid and 3-substituted congeners--conformationally constrained analogs of phenylalanine, naphthylalanine, and leucine.
作者信息
Hanessian S, Bernstein N, Yang R Y, Maguire R
机构信息
Department of Chemistry, Université de Montréal, Québec, Canada.
出版信息
Bioorg Med Chem Lett. 1999 May 17;9(10):1437-42. doi: 10.1016/s0960-894x(99)00218-8.
Abstract
Enantiopure L-azetidine-2-carboxylic acid, the (3R)-phenyl, (3R)-naphthyl and (3S)-isopropyl analogs were prepared based on a zinc-mediated asymmetric addition of allylic halides to the camphor sultam derivative of glyoxylic acid O-benzyl oxime.
摘要
Zotero 插件