Tsirel'nikov N I, Tsirel'nikova T G
Biull Eksp Biol Med. 1976 Aug;82(8):1007-9.
Intragastric administration of CCl4 (0.3 ml per 100 g of body weight) to female rats caused a marked injury of the placental tissue and particularly of the chorionic epithelium of the labyrinthine portion with the maximal development of dystrophic necrobiotic processes on the 14th-16th day of pregnancy (when the poison was administered 48 hours before the animal was sacrificed). There was noted an increase in the number of mitoses in the epithelial cells at all the periods, and a statistically significant enlargement of the nuclei and the nucleoli of the cytotrophoblastic cells on the 17th--18th day of the intrauterine fetal development. CCl4 administration led to the reduction in the content of histochemically detectable glycogen in the cytoplasm of the chorionic epithelium and to the fall in the amount of amylase-resistant glycoproteins, protein and RNA in dystrophically altered cells.
给雌性大鼠胃内注射四氯化碳（每100克体重0.3毫升）会导致胎盘组织尤其是迷路部分的绒毛膜上皮显著损伤，在妊娠第14 - 16天（即在处死动物前48小时给予毒物时）出现营养不良性坏死过程的最大发展。在所有时期均观察到上皮细胞有丝分裂数量增加，在子宫内胎儿发育的第17 - 18天，细胞滋养层细胞核和核仁有统计学意义的增大。给予四氯化碳导致绒毛膜上皮细胞质中组织化学可检测到的糖原含量降低，以及营养不良性改变细胞中抗淀粉酶糖蛋白、蛋白质和RNA含量下降。
