Arakawa M, Takakuwa K, Honda K, Tamura M, Kurabayashi T, Tanaka K
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
Fertil Steril. 1999 Jun;71(6):1103-7. doi: 10.1016/s0015-0282(99)00117-x.
To determine whether sera that show a positive anticardiolipin test result have a suppressive effect on the proliferation of endothelial cells collected from human umbilical veins.
Retrospective in vitro study.
University hospital outpatient clinic for the treatment of infertility.
PATIENT(S): Thirteen patients with recurrent fetal miscarriages who were positive for anticardiolipin antibody and 14 patients with recurrent miscarriages who were negative for anticardiolipin antibody.
INTERVENTION(S): Serum was obtained from each patient.
MAIN OUTCOME MEASURE(S): Suppressive effect of the sera on the culture of human umbilical vein endothelial cells.
RESULT(S): The proliferation of human umbilical vein endothelial cells decreased significantly in cultures that contained sera showing positive anticardiolipin antibody activity that had been collected from patients with recurrent fetal miscarriages.
CONCLUSION(S): The results strongly suggest that anticardiolipin antibody has a suppressive effect on the proliferation of human umbilical vein endothelial cells.
确定抗心磷脂检测结果呈阳性的血清是否对从人脐静脉采集的内皮细胞增殖具有抑制作用。
回顾性体外研究。
大学医院不孕症门诊。
13例抗心磷脂抗体呈阳性的复发性胎儿流产患者和14例抗心磷脂抗体呈阴性的复发性流产患者。
从每位患者采集血清。
血清对人脐静脉内皮细胞培养的抑制作用。
在含有从复发性胎儿流产患者采集的抗心磷脂抗体活性呈阳性血清的培养物中，人脐静脉内皮细胞的增殖显著降低。
结果强烈表明抗心磷脂抗体对人脐静脉内皮细胞的增殖具有抑制作用。
