从中国红豆杉（南方红豆杉）针叶中分离并鉴定一种新型双环紫杉烷二萜的结构。

Isolation and structural determination of a novel bicyclic taxane diterpene from needles of the Chinese yew, Taxus mairei.

作者信息

Shi Q W, Oritani T, Sugiyama T, Yamada T

机构信息

Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.

出版信息

Biosci Biotechnol Biochem. 1999 Apr;63(4):756-9. doi: 10.1271/bbb.63.756.

DOI:10.1271/bbb.63.756

PMID:10361690

Abstract

A novel bicyclic taxane diterpene with a rare 12-membered ring was isolated from needles of the Chinese yew, Taxus mairei, and its structure was established as (3E, 8E)-2 alpha, 7 beta, 9, 10 beta, 13 alpha, 20-hexaacetoxy-5(2'-acetoxy-cinnamoyloxy)-3,8-secotaxa -3,8,11-triene (1) with the help of 1D and 2D NMR data. The relative stereochemistry was deduced from a NOESY experiment.

摘要

从中国红豆杉（Taxus mairei）的针叶中分离出一种具有罕见十二元环的新型双环紫杉烷二萜，并借助一维和二维核磁共振数据确定其结构为(3E, 8E)-2α, 7β, 9, 10β, 13α, 20-六乙酰氧基-5(2'-乙酰氧基肉桂酰氧基)-3,8-裂紫杉-3,8,11-三烯（1）。相对立体化学通过核Overhauser效应光谱实验推导得出。