Kobayashi J, Sekiguchi M, Shimamoto S, Shigemori H, Ohsaki A
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
J Nat Prod. 2000 Nov;63(11):1576-9. doi: 10.1021/np000355w.
Four new nitrogen-containing clerodane diterpenoids, echinophyllins C-F (1-4), were isolated from the leaves of the Brazilian medicinal plant Echinodorus macrophyllus ("Chapéu-de-couro"), and their structures and relative stereochemistry were elucidated from their spectroscopic data. Compounds 1-4 possess an alpha,beta-unsaturated gamma-lactam ring consisting of a clerodane diterpene unit and an amine moiety.
从巴西药用植物大叶刺果泽泻（“Chapéu-de-couro”）的叶子中分离出四种新的含氮克罗烷二萜类化合物，即刺果泽泻素C - F（1 - 4），并根据其光谱数据阐明了它们的结构和相对立体化学。化合物1 - 4具有一个由克罗烷二萜单元和一个胺部分组成的α，β - 不饱和γ - 内酰胺环。
