人类巨细胞病毒的新型结构蛋白pUL25定位于病毒被膜中。
The novel structural protein of human cytomegalovirus, pUL25, is localized in the viral tegument.
作者信息
Zini N, Battista M C, Santi S, Riccio M, Bergamini G, Landini M P, Maraldi N M
机构信息
Institute of Normal and Pathologic Cytomorphology, C.N.R., c/o I.O.R., Bologna, Italy.
出版信息
J Virol. 1999 Jul;73(7):6073-5. doi: 10.1128/JVI.73.7.6073-6075.1999.
Abstract
Human cytomegalovirus UL25 codes for a structural phosphoprotein of 85 kDa (C. J. Baldick and T. Shenk, J. Virol. 70:6097-6105, 1996; M. C. Battista et al., J. Virol. 73:3800-3809, 1999). In this study we analyzed the intracellular and intraviral localization of pUL25 by confocal and immunoelectron microscopy and found that pUL25 is a component of the viral tegument and the dense body matrix, acquired during the late cytoplasmic phase of virus maturation.
摘要
人巨细胞病毒UL25编码一种85 kDa的结构磷蛋白（C. J. 鲍迪克和T. 申克，《病毒学杂志》70:6097 - 6105，1996；M. C. 巴蒂斯塔等人，《病毒学杂志》73:3800 - 3809，1999）。在本研究中，我们通过共聚焦显微镜和免疫电子显微镜分析了pUL25在细胞内和病毒内的定位，发现pUL25是病毒被膜和致密体基质的一个组成部分，在病毒成熟的细胞质后期获得。
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