Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P, Alafuzoff I
Department of Neuroscience and Neurology, Kuopio University Hospital, Kuopio, Finland.
Dement Geriatr Cogn Disord. 1999 Jul-Aug;10(4):252-7. doi: 10.1159/000017128.
Significantly increased glial fibrillary acidic protein (GFAP) expression was seen in postmortem brain tissue from demented patients with Alzheimer's disease (AD) (73 cases, 61 females/12 males, mean age 84 +/- 9 years) compared to controls (22 cases, 10 females/12 males, mean age 78 +/- 9 years). In demented patients, the GFAP expression, counts of AD lesions, senile/neuritic plaques (SP/NP) and neurofibrillary tangles (NFT) were higher in patients carrying the apolipoprotein E (ApoE) epsilon4 allele compared to those without the ApoE epsilon4 allele. The astrogliosis correlated significantly with the counts of NFT in demented patients both with and without the ApoE epsilon4 allele. Furthermore, the astrogliosis correlated significantly with the counts of SP/NP, but this correlation, however, was influenced by the ApoE epsilon4 allele, being significant only in those cases without the ApoE epsilon4 allele. Our results demonstrate that not only the extent of AD lesions and GFAP expression, but also the relationship between AD lesions and the GFAP expression is influenced by the ApoE epsilon4 allele.
与对照组（22例，10名女性/12名男性，平均年龄78±9岁）相比，在患有阿尔茨海默病（AD）的痴呆患者（73例，61名女性/12名男性，平均年龄84±9岁）的死后脑组织中，胶质纤维酸性蛋白（GFAP）表达显著增加。在痴呆患者中，与未携带载脂蛋白E（ApoE）ε4等位基因的患者相比，携带ApoE ε4等位基因的患者GFAP表达、AD病变计数、老年斑/神经炎斑（SP/NP）和神经原纤维缠结（NFT）更高。在携带和未携带ApoE ε4等位基因的痴呆患者中，星形胶质细胞增生均与NFT计数显著相关。此外，星形胶质细胞增生与SP/NP计数显著相关，但这种相关性受ApoE ε4等位基因影响，仅在未携带ApoE ε4等位基因的病例中显著。我们的结果表明，不仅AD病变程度和GFAP表达，而且AD病变与GFAP表达之间的关系均受ApoE ε4等位基因影响。
