Sparks D L, Scheff S W, Liu H, Landers T, Danner F, Coyne C M, Hunsaker J C
Sanders-Brown Center on Aging, Lexington, KY 40536-0230, USA.
J Neurol Sci. 1996 Jun;138(1-2):97-104. doi: 10.1016/0022-510x(96)00008-1.
The apolipoprotein E genotype and cortical senile plaque (SP) and cortical and hippocampal neurofibrillary tangle (NFT) densities were determined in non-demented individuals and neuropathologically confirmed AD patients. The non-demented population was further subdivided according to presence or absence of pathologically established critical coronary artery disease (cCAD), hypertension (HyperT), or neither (non-heart disease; non-HD). The apolipoprotein E4 (APOE4) allele incidence and dose frequencies were increased in the AD, cCAD and HyperT groups compared to the non-HD controls. The mean number of SP and NFT was significantly increased with the presence of the APOE4 allele within the entire population. After grouping the non-demented subjects according to cardiac status, SP but not NFT density was increased among those individuals with the APOE4 genotype. In HyperT, the increased density of SP also correlated to the APOE4 allele dose frequency. The density of SP and NFT was increased in all regions of AD brain compared to all other non-demented groups, but no significant difference was found between AD patients with or without an APOE4 allele. These two AD groups were age-matched, but could not be matched for disease duration. The data suggest a relationship between heart disease, APOE4 genotype and the presence of SP regardless of cognitive status.
在非痴呆个体和经神经病理学确诊的阿尔茨海默病（AD）患者中，测定了载脂蛋白E基因型以及皮质老年斑（SP）、皮质和海马神经原纤维缠结（NFT）的密度。根据是否存在经病理证实的严重冠状动脉疾病（cCAD）、高血压（HyperT）或两者皆无（非心脏病；非HD），将非痴呆人群进一步细分。与非HD对照组相比，AD、cCAD和HyperT组中载脂蛋白E4（APOE4）等位基因发生率和剂量频率均升高。在整个人群中，随着APOE4等位基因的存在，SP和NFT的平均数量显著增加。根据心脏状况对非痴呆受试者进行分组后，APOE4基因型个体中SP密度增加，但NFT密度未增加。在HyperT中，SP密度增加也与APOE4等位基因剂量频率相关。与所有其他非痴呆组相比，AD脑所有区域的SP和NFT密度均增加，但携带或不携带APOE4等位基因的AD患者之间未发现显著差异。这两组AD患者年龄匹配，但疾病持续时间无法匹配。数据表明，无论认知状态如何，心脏病、APOE4基因型与SP的存在之间存在关联。
