Weiss L, Glaves D
Int J Cancer. 1976 Dec 15;18(6):774-7. doi: 10.1002/ijc.2910180608.
The early arrest patterns of a methylcholanthrene-induced fibrosarcoma were determined after injection of 125IUdR-labelled cells into the systemic circulation of mice bearing transplanted lymphosarcomas, and of normal animals. Similar experiments were performed using radiolabelled lymphosarcoma cells and normal or fibrosarcoma-bearing mice. The results showed that shifts in normal distribution patterns previously observed in tumor-bearing animals injected with cells of the same type as that borne by the animal, were not detectable when cells of a different tumor type were injected. Peritoneal exudate cell migration inhibition assays showed little immunologic cross-reactivity between the two tumors and, together with the results of the distribution studies, indicated that alterations of early arrest patterns in mice sensitized to their tumor is an immunologically specific phenomenon.
将125IUdR标记的细胞注入患有移植性淋巴肉瘤的小鼠及正常动物的体循环后，测定了甲基胆蒽诱导的纤维肉瘤的早期滞留模式。使用放射性标记的淋巴肉瘤细胞以及正常或患有纤维肉瘤的小鼠进行了类似实验。结果表明，当注射不同肿瘤类型的细胞时，在注射与动物所患肿瘤相同类型细胞的荷瘤动物中先前观察到的正常分布模式的变化无法检测到。腹膜渗出细胞迁移抑制试验显示这两种肿瘤之间几乎没有免疫交叉反应，并且与分布研究结果一起表明，对其肿瘤致敏的小鼠中早期滞留模式的改变是一种免疫特异性现象。
