Backhaus M, Kamradt T, Sandrock D, Loreck D, Fritz J, Wolf K J, Raber H, Hamm B, Burmester G R, Bollow M
Department of Rheumatology and Clinical Immunology, Charité University Hospital, Humboldt University of Berlin, Germany.
Arthritis Rheum. 1999 Jun;42(6):1232-45. doi: 10.1002/1529-0131(199906)42:6<1232::AID-ANR21>3.0.CO;2-3.
A prospective study was performed comparing conventional radiography, 3-phase bone scintigraphy, ultrasound, and magnetic resonance imaging (MRI) with precontrast and dynamic postcontrast examinations in 60 patients with various forms of arthritis including rheumatoid arthritis (RA), spondyl-arthropathy, and arthritis associated with connective tissue disease.
A total of 840 finger joints were examined clinically and by all 4 imaging methods. Experienced investigators blinded to the clinical findings and diagnoses analyzed all methods independently of each other. The patients were divided into 2 groups. Group 1 included 32 patients (448 finger joints) without radiologic signs of destructive arthritis (Larsen grades 0-1) of the evaluated hand and wrist and group 2 included 28 patients (392 finger joints) with radiographs revealing erosions (Larsen grade 2) of the evaluated hand and/or wrist.
Clinical evaluation, scintigraphy, MRI, and ultrasound were each more sensitive than conventional radiography in detecting inflammatory soft tissue lesions as well as destructive joint processes in arthritis patients in group 1. All differences were statistically significant. We found ultrasound to be even more sensitive than MRI in the detection of synovitis. MRI detected erosions in 92 finger joints (20%; 26 patients) in group 1 that had not been detected by conventional radiography.
Our data indicate that MRI and ultrasound are valuable diagnostic methods in patients with arthritis who have normal findings on radiologic evaluation.
进行一项前瞻性研究,比较传统X线摄影、三相骨闪烁显像、超声和磁共振成像(MRI)以及造影前和动态造影后检查在60例患有各种形式关节炎(包括类风湿关节炎(RA)、脊柱关节病和结缔组织病相关关节炎)患者中的应用。
对总共840个手指关节进行临床检查以及所有4种成像方法的检查。对临床发现和诊断不知情的经验丰富的研究人员相互独立地分析所有方法。患者分为2组。第1组包括32例患者(448个手指关节),其评估的手和腕部无破坏性关节炎的放射学征象(Larsen分级0 - 1级),第2组包括28例患者(392个手指关节),其X线片显示评估的手和/或腕部有侵蚀(Larsen分级2级)。
在检测第1组关节炎患者的炎性软组织病变以及破坏性关节病变方面,临床评估、闪烁显像、MRI和超声各自均比传统X线摄影更敏感。所有差异均具有统计学意义。我们发现超声在检测滑膜炎方面比MRI更敏感。MRI在第1组中检测到92个手指关节(20%;26例患者)有侵蚀,而传统X线摄影未检测到。
我们的数据表明,对于放射学评估结果正常的关节炎患者,MRI和超声是有价值的诊断方法。