新生儿脑膜炎的鞘内抗生素治疗
Intrathecal antibiotic therapy for neonatal meningitis.
作者信息
Yeung C Y
出版信息
Arch Dis Child. 1976 Sep;51(9):686-90. doi: 10.1136/adc.51.9.686.
Abstract
Twenty infants with neonatal meningitis were treated with systemic and lumbar intrathecal antibiotics upon initial diagnosis. Failure to sterilize the CSF in 2-3 days was associated with evidence of ventriculitis in these infants who were then treated with intraventricular antibiotics. 4 infants died, but only 2 of them may be regarded as treatment failure. It is suggested that many deaths from neonatal meningitis may be preventable by early detection and treatment of ventriculitis with intraventricular antibiotics.
摘要
20例新生儿脑膜炎患儿在初诊时接受了全身及鞘内注射抗生素治疗。2至3天内脑脊液未能除菌与这些患儿出现脑室炎迹象相关，随后对其使用了脑室内抗生素治疗。4例患儿死亡，但其中仅有2例可被视为治疗失败。有人提出，通过早期发现脑室炎并使用脑室内抗生素治疗，许多新生儿脑膜炎导致的死亡可能是可预防的。
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