[患有炎症性和非炎症性脑膜的患者脑脊液中的庆大霉素浓度（作者译）]

[Gentamicin concentrations in cerebrospinal fluid of patients with inflamed and uninflamed meninges (author's transl)].

作者信息

Brückner O, Alexander M, Martens F

出版信息

Infection. 1980;8(2):86-9. doi: 10.1007/BF01639153.

Abstract

Determinations of gentamicin levels in serum and cerebrospinal fluid were performed in 11 tests of eight patients suffering from memingitis and in 18 tests of eight patients after neurosurgical operations. Neurosurgical operations had been performed in this group at least four days prior to testing. Only in four tests in neurosurgical patients were the gentamicin levels in CSF higher than the lowest measurable concentration of 0.4 mcg/ml, serum levels in this group ranged from below 0.4 mcg/ml up to 5.0 mcg/ml. No gentamicin level in CSF exceeded 1.5 mcg/ml. Gentamicin levels in CSF of patients with meningitis ranged from below 0.4 mcg/ml to 5.66 mcg/ml. This equals a CSF/serum ratio of 7.4-57.6%, mean 25.8%.

摘要

对8例脑膜炎患者进行了11次血清和脑脊液庆大霉素水平测定，并对8例神经外科手术后患者进行了18次测定。该组患者在检测前至少4天接受了神经外科手术。神经外科患者中只有4次检测脑脊液中的庆大霉素水平高于最低可测浓度0.4 mcg/ml，该组血清水平范围为低于0.4 mcg/ml至5.0 mcg/ml。脑脊液中庆大霉素水平均未超过1.5 mcg/ml。脑膜炎患者脑脊液中庆大霉素水平范围为低于0.4 mcg/ml至5.66 mcg/ml。这相当于脑脊液/血清比值为7.4 - 57.6%，平均为25.8%。