Wirth K, Hengstmann J H, Langebartels F H, Träger S
Arzneimittelforschung. 1976;26(9):1709-15.
Within 5 min 5 g of ampicillin, oxacillin and carbenicillin, respectively, were administered i.v. to patients with normal kidney function. Plasma levels of the antibiotic activity were measured up to 6 h following the injection. Urine was collected at intervals up to 8 h and the cumulative urinary excretion calculated. Furtheron, biologic half-life, volumes of distribution, total and renal clearance and area under the serum level curve have been assessed for the one- and the two-compartment model. For this model the amounts of drug in central and peripheral compartments were simulated. The statistical evaluation resulted in a highly significantly better fit when the data were analyzed according to the two-compartment model. Despite of these differences the physiological consequences of using the parameters of the one-compartment model were not significantly different.
在5分钟内，分别向肾功能正常的患者静脉注射5克氨苄西林、苯唑西林和羧苄西林。在注射后长达6小时内测量抗生素活性的血浆水平。每隔一段时间收集尿液，直至8小时，并计算累积尿排泄量。此外，还评估了单室模型和双室模型的生物半衰期、分布容积、总清除率和肾清除率以及血清水平曲线下的面积。对于该模型，模拟了中央室和周边室中的药物量。当根据双室模型分析数据时，统计评估结果显示拟合度显著更好。尽管存在这些差异，但使用单室模型参数的生理后果并无显著差异。
