Agapitova I V, Bobrov V I, Trubnikov V I, Iakovlev V P
Antibiotiki. 1984 May;29(5):370-3.
Penetration of 2 penicillins with different indices of serum protein binding in the tissues of rats with aseptic inflammation was studied. The pharmacokinetics of both penicillins in the blood serum (total preparation) did not differ. However, the level of the ampicillin free fraction was much higher than that of oxacillin. In the inflammation exudate and inflamed tissues, the maximum concentrations of free ampicillin and the area below its pharmacokinetic curve were also higher than those of oxacillin. The rate of elimination of both antibiotics from the exudate was the same. The period of half elimination of the drugs from the exudate and inflamed tissue was significantly higher than the period of their half elimination from the blood serum. High positive correlation between the ampicillin levels in the blood serum and inflamed and intact tissues was shown. As for oxacillin, positive correlation between its levels in the blood serum and inflamed tissue was observed.
研究了两种血清蛋白结合指数不同的青霉素在无菌性炎症大鼠组织中的渗透情况。两种青霉素在血清（全制剂）中的药代动力学无差异。然而，氨苄西林的游离分数水平远高于苯唑西林。在炎症渗出液和炎症组织中，游离氨苄西林的最大浓度及其药代动力学曲线下面积也高于苯唑西林。两种抗生素从渗出液中的消除速率相同。药物从渗出液和炎症组织中的半衰期明显高于其从血清中的半衰期。血清中氨苄西林水平与炎症及完整组织之间呈现高度正相关。至于苯唑西林，观察到其血清水平与炎症组织之间存在正相关。
