Russell P S, John J K
Department of Psychiatry, Christian Medical College, Vellore, India.
Pediatr Rehabil. 1999 Jan-Mar;3(1):1-4. doi: 10.1080/136384999289621.
Self-injurious behaviour continues to be a drain on the resources for rehabilitation of the children with developmental disabilities. Pathogenesis and therapy seems fragmentary, with virtually every major neurotransmitter system being identified as the putative substrate for self-injurious behaviour. This phenomenon as it cuts across the diagnostic boundaries, although it is suggestive of a heterogeneous neurochemical basis, should call for the exploration of the biological event preceding the neurochemical cascade resulting in the behaviour. The authors argue that kindling is the preceding neurophysiological event resulting in self-injurious behaviour and, thus, can be effectively prevented pharmacologically.
自伤行为持续消耗发育障碍儿童的康复资源。发病机制和治疗方法似乎支离破碎，几乎每个主要神经递质系统都被确定为自伤行为的假定底物。这种跨越诊断界限的现象，尽管提示存在异质性神经化学基础，但仍需要探索导致该行为的神经化学级联反应之前的生物学事件。作者认为，点燃效应是导致自伤行为的先前神经生理事件，因此可以通过药物有效预防。
