Baldi I, Brochard P, Mohammed-Brahim B, Rolland P, Salamon R
Laboratoire Santé Travail Environnement, Université Victor Segalen Bordeaux 2.
Rev Epidemiol Sante Publique. 1999 Apr;47(2):165-74.
The extensively growing use of pesticides in the last decades has led to great improvements in agriculture but also to threats for human health. Studying long term effects to assess individual exposures encounters difficulties in exposure assessment. This article summarizes retrospective methods for assessing occupational exposures to pesticides currently used in epidemiological studies. Questionnaires, environmental and biological monitoring constitute direct assessment of exposure, in an individual approach. But the validity of questionnaires is often poor and the metrology rarely reflects past exposures. Some indirect measures have been used together with job exposure matrices. To establish dose-response relationships is important to quantify the risk, but needs accurate exposure assessment based on quantitative indexes.
在过去几十年里，农药的广泛使用在促进农业大幅发展的同时，也对人类健康构成了威胁。研究长期影响以评估个体接触情况时，接触评估面临困难。本文总结了目前在流行病学研究中用于评估职业性农药接触的回顾性方法。问卷调查、环境和生物监测以个体方式构成了接触的直接评估。但问卷的有效性往往较差，且测量方法很少能反映过去的接触情况。一些间接测量方法已与工作接触矩阵一起使用。建立剂量反应关系对于量化风险很重要，但需要基于定量指标进行准确的接触评估。
