Okai O, Watanabe A
Department of Clinical Physiology, Kyorin University School of Health Sciences, Hachioji, Japan.
Med Biol Eng Comput. 1998 Sep;36(5):587-91. doi: 10.1007/BF02524428.
The systolic hump in the aortic blood pressure wave is defined as the aortic-resistance component proportional to the aortic blood flow superimposed on the windkessel component. An electrical analogue comprising a series resistance (aortic resistance) plus a resistance (peripheral resistance) and capacitance (aortic compliance) in parallel (i.e. windkessel component) is used for analysis. Curve fitting using the least-squares method is performed on calculated and measured blood pressure waves from dogs under haemodynamical conditions induced by infusion of three drugs (noradrenaline, isoproterenol and acetylcholine). The curve fitting RMS (root mean square) errors are < 3% for blood pressure waves and < 30% for blood flow waves, with good agreement between measured and calculated blood flow waveforms. Infusion of noradrenaline and acetylcholine is found to induce a significant decrease and increase in the aortic resistance, respectively. Although only a small fraction of the blood pressure wave, the systolic hump has a marked effect on the systolic pressure waveform.
