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两个动脉有效反射位点对心脏而言可能看起来像一个。

Two arterial effective reflecting sites may appear as one to the heart.

作者信息

Burattini R, Knowlen G G, Campbell K B

机构信息

Department of Electronics and Automatica, University of Ancona, Italy.

出版信息

Circ Res. 1991 Jan;68(1):85-99. doi: 10.1161/01.res.68.1.85.

Abstract

The relation between reflected waves and features of ascending aortic pressure waveforms and impedance patterns was investigated with a modified T-tube model of the systemic arterial circulation. Ascending aortic pressure and flow and descending aortic flow were measured in 10 dogs under basal conditions and under the effect of an agent (methoxamine) that caused vasoconstriction and an increase of mean aortic pressure. A broad range of aortic pressure amplitudes and features was obtained. These waveshapes were classified into four groups. Under basal conditions, cases for which a prominent diastolic fluctuation was present (n = 8) were grouped in A. Cases for which this fluctuation was absent (n = 2) were grouped in B. Groups C (n = 4) and D (n = 3) included cases that, under vasoconstricted conditions, did or did not display, respectively, a diastolic fluctuation in pressure. Arterial T-tube model parameters were estimated by simultaneously fitting the model to both ascending and descending aortic flow with aortic pressure as input. A good fit was obtained in any case considered. After parameter estimation, forward and reflected waves and impedance patterns at the entrance of head circulation (head and upper limbs) and body circulation (trunk and lower limbs) as well as their merger in the ascending aorta were determined. T-tube input impedance compared well with impedance data points obtained from the ratio of corresponding harmonics of ascending aortic pressure and flow. In some cases (group A), modulus and phase spectra displayed two distinct minima, in the range from 0 to 10 Hz. In some other circumstances, these minima were less distinct (groups B and C) and could even appear as one (group D). Whether one or two minima appeared in the ascending aortic impedance spectra at low frequency and whether a prominent diastolic fluctuation did or did not appear in aortic pressure, pressure and flow waveshapes proximal to the heart were explained by the presence of two effective reflecting sites in the systemic circulation. In group B, a diastolic fluctuation in pressure was absent despite the fact that head-end and body-end reflected waves were distinct. This happened because body-end reflected waves peaked corresponding to a minimum of the head-end reflected wave. In group D, a diastolic fluctuation in aortic pressure was absent because the body-end reflected wave moved into systole and superimposed on the head-end reflected wave. This superimposition was due to increased pulse wave velocity in the body transmission path as a result of decreased arterial distensibility.(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

利用改良的体循环动脉T型管模型,研究了反射波与升主动脉压力波形特征及阻抗模式之间的关系。在基础条件下以及在引起血管收缩和平均主动脉压升高的药物(甲氧明)作用下,测量了10只犬的升主动脉压力、血流以及降主动脉血流。获得了广泛的主动脉压力幅度和特征。这些波形被分为四组。在基础条件下,存在明显舒张期波动的病例(n = 8)归为A组。不存在这种波动的病例(n = 2)归为B组。C组(n = 4)和D组(n = 3)分别包括在血管收缩条件下出现或未出现压力舒张期波动的病例。通过将模型与以主动脉压力为输入的升主动脉和降主动脉血流同时拟合来估计动脉T型管模型参数。在任何考虑的情况下都获得了良好的拟合。参数估计后,确定了头部循环(头部和上肢)和体循环(躯干和下肢)入口处的前向波和反射波以及阻抗模式,以及它们在升主动脉中的合并情况。T型管输入阻抗与从升主动脉压力和血流的相应谐波比值获得的阻抗数据点比较良好。在某些情况下(A组),模量和相位谱在0至10Hz范围内显示出两个明显的最小值。在其他一些情况下,这些最小值不太明显(B组和C组),甚至可能表现为一个(D组)。升主动脉阻抗谱在低频时出现一个还是两个最小值,以及主动脉压力中是否出现明显的舒张期波动,心脏近端的压力和血流波形可以通过体循环中两个有效反射部位的存在来解释。在B组中,尽管头部末端和身体末端的反射波不同,但压力的舒张期波动不存在。这是因为身体末端反射波的峰值对应于头部末端反射波的最小值。在D组中,主动脉压力的舒张期波动不存在,因为身体末端反射波进入收缩期并叠加在头部末端反射波上。这种叠加是由于动脉扩张性降低导致身体传输路径中脉搏波速度增加所致。(摘要截断于400字)

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