Lutzemberger L, Salvetti O
Department of Neuroscience, University of Pisa, Italy.
Med Biol Eng Comput. 1998 Nov;36(6):661-6. doi: 10.1007/BF02518866.
The determination of the volume of eye muscles is a problem of considerable interest in Graves' ophtalmopathy both with respect to the diagnostic quantisation of the disease and to the measured assessment of the effectiveness of pharmacological treatment. The aim of this research is to design and test an advanced method for processing computerised tomography (CT) orbital images in order to obtain a three-dimensional reconstruction of infra-orbital muscle structures and to analyse them from a morphometric viewpoint. CT images of subjects suffering from Graves' disease were acquired before and after pharmacological treatment with immunosuppressors. They were then processed along with CT images of an anatomical phantom of known volume and fusiform morphology in order to assess the reliability of the procedure and to calculate the effect of the different modalities of acquisition and processing of CT images on the error in volume calculation.
眼肌体积的测定在格雷夫斯眼病中是一个备受关注的问题，这既涉及到疾病的诊断量化，也涉及到药物治疗效果的测量评估。本研究的目的是设计并测试一种先进的方法来处理计算机断层扫描（CT）眼眶图像，以获得眶下肌肉结构的三维重建，并从形态计量学的角度对其进行分析。患有格雷夫斯病的受试者在使用免疫抑制剂进行药物治疗前后均获取了CT图像。然后将这些图像与已知体积和梭形形态的解剖模型的CT图像一起进行处理，以评估该程序的可靠性，并计算CT图像不同采集和处理方式对体积计算误差的影响。
