Forbes G, Gorman C A, Brennan M D, Gehring D G, Ilstrup D M, Earnest F
AJNR Am J Neuroradiol. 1986 Jul-Aug;7(4):651-6.
Pixel-calibrated volume measurements of muscle and fat in the bony orbit were made from CT scans of 72 patients with Graves' disease, with and without ophthalmopathy, to define characteristic changes present in clinical subgroups. Measurement abnormalities were detected in 87% of Graves' patients with clinically detectable ophthalmopathy and in 70% of hyperthyroid patients without clinical eye signs. Abnormal enlargement of the fat compartment in addition to muscle enlargement was found in 46% of patients with clinical ophthalmopathy; 8% of patients had only increased size of the fat compartment with normal muscle volumes. The ratio of muscle to fat and the volumes of orbital muscle and fat all varied widely in each clinical subgroup. Statistically significant (p less than 0.0001) total muscle-volume increase (range = 3.68-17.06 cm3) and borderline significant (p less than 0.06) fat-compartment increase (range = 6.05-22.63 cm3) were documented in all clinical subgroups. The degree of change of muscle and fat volumes was independent of the clinical group. Abnormal changes were found in the contralateral orbit in six of seven patients who appeared to have unilateral ophthalmopathy on clinical examination. A higher frequency of medial and inferior muscle enlargement was documented in all clinical subgroups.
对72例患有或未患有眼病的格雷夫斯病患者的CT扫描进行眼眶内肌肉和脂肪的像素校准体积测量，以确定临床亚组中存在的特征性变化。在87%有临床可检测眼病的格雷夫斯病患者和70%无临床眼部体征的甲状腺功能亢进患者中检测到测量异常。在46%有临床眼病的患者中发现除肌肉增大外脂肪隔异常增大；8%的患者脂肪隔大小增加而肌肉体积正常。每个临床亚组中肌肉与脂肪的比例以及眼眶肌肉和脂肪的体积差异都很大。所有临床亚组均记录到具有统计学意义（p<0.0001）的总肌肉体积增加（范围=3.68-17.06 cm³）和临界显著（p<0.06）的脂肪隔增加（范围=6.05-22.63 cm³）。肌肉和脂肪体积的变化程度与临床分组无关。在临床检查中看似单侧眼病的7例患者中，有6例对侧眼眶发现异常变化。所有临床亚组中均记录到更高频率的内侧和下侧肌肉增大。
