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Lymphopenia and lung complications in patients with coronavirus disease-2019 (COVID-19): A retrospective study based on clinical data.淋巴细胞减少症与新型冠状病毒病-2019（COVID-19）患者的肺部并发症：基于临床数据的回顾性研究。
J Med Virol. 2021 Sep;93(9):5425-5431. doi: 10.1002/jmv.27060. Epub 2021 May 13.
2
Lymphopenia as a Biological Predictor of Outcomes in COVID-19 Patients: A Nationwide Cohort Study.淋巴细胞减少作为COVID-19患者预后的生物学预测指标：一项全国性队列研究。
Cancers (Basel). 2021 Jan 26;13(3):471. doi: 10.3390/cancers13030471.
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Incidental lymphopenia and mortality: a prospective cohort study.偶然发现的淋巴细胞减少症与死亡率：一项前瞻性队列研究。
CMAJ. 2020 Jan 13;192(2):E25-E33. doi: 10.1503/cmaj.191024.
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Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner.虚拟记忆T细胞以白细胞介素-15依赖的方式发育并介导旁观者保护性免疫。
Nat Commun. 2016 Apr 21;7:11291. doi: 10.1038/ncomms11291.
5
Regeneration of the aged thymus by a single transcription factor.单一转录因子可实现衰老胸腺的再生。
Development. 2014 Apr;141(8):1627-37. doi: 10.1242/dev.103614.
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Virtual memory CD8 T cells display unique functional properties.虚拟内存 CD8 T 细胞表现出独特的功能特性。
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13498-503. doi: 10.1073/pnas.1307572110. Epub 2013 Jul 29.
7
Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.自身反应性 T 细胞在感染过程中绕过负选择，并对自身抗原刺激产生反应。
J Exp Med. 2012 Sep 24;209(10):1769-79. doi: 10.1084/jem.20120905. Epub 2012 Sep 17.
8
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.在小鼠中，外周初始 T 细胞的维持依赖于胸腺输出，但在人类中并非如此。
Immunity. 2012 Feb 24;36(2):288-97. doi: 10.1016/j.immuni.2012.02.006.
9
Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation.凋亡调节因子 Fas 和 Bim 协同控制 T 淋巴细胞稳态增殖。
Eur J Immunol. 2010 Nov;40(11):3043-53. doi: 10.1002/eji.201040577. Epub 2010 Oct 27.
10
Lymphocyte proliferation in immune-mediated diseases.免疫介导性疾病中的淋巴细胞增殖。
Trends Immunol. 2009 Sep;30(9):430-8. doi: 10.1016/j.it.2009.06.002. Epub 2009 Aug 19.

淋巴细胞减少与T细胞再生机制

Lymphopenia and Mechanisms of T-Cell Regeneration.

作者信息

Saidakova E V

机构信息

Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences-Branch of Perm Federal Research Center, Ural Branch, Russian Academy of Sciences, 614081 Perm, Russia.

出版信息

Cell tissue biol. 2022;16(4):302-311. doi: 10.1134/S1990519X2204006X. Epub 2022 Aug 8.

DOI:10.1134/S1990519X2204006X
PMID:35967247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9358362/
Abstract

Chronic lymphopenia, in particular, T-lymphocyte deficiency, increases the risk of death from cancer, cardiovascular and respiratory diseases and serves as a risk factor for a severe course and poor outcome of infectious diseases such as COVID-19. The regeneration of T-lymphocytes is a complex multilevel process, many questions of which still remain unanswered. The present review considers two main pathways of increasing the T-cell number in lymphopenia: production in the thymus and homeostatic proliferation in the periphery. Literature data on the signals that regulate each pathway are summarized. Their contribution to the quantitative and qualitative restoration of the immune cell pool is analyzed. The features of CD4 and CD8 T-lymphocytes' regeneration are considered.

摘要

尤其是慢性淋巴细胞减少，特别是T淋巴细胞缺乏，会增加因癌症、心血管疾病和呼吸系统疾病导致死亡的风险，并成为诸如COVID-19等传染病病程严重和预后不良的风险因素。T淋巴细胞的再生是一个复杂的多水平过程，其中许多问题仍未得到解答。本综述探讨了淋巴细胞减少症中增加T细胞数量的两条主要途径：胸腺中的产生和外周的稳态增殖。总结了关于调节每条途径的信号的文献数据。分析了它们对免疫细胞库定量和定性恢复的贡献。还考虑了CD4和CD8 T淋巴细胞再生的特点。