Küpeli S, Soygür T, Yilmaz E, Aytaç S
Department of Urology, University of Ankara, Medical School, Ankara, Turkey.
BJU Int. 1999 May;83(7):783-5. doi: 10.1046/j.1464-410x.1999.00002.x.
To assess the effect of transurethral electrovaporization of the prostate (TUVP) on serum prostate specific antigen (PSA) concentration.
Twenty-five men (mean age 61.7 years) with symptoms of prostatism underwent TUVP. Serum PSA levels were determined before any prostatic manipulation, and again at 1 and 24 h after TUVP. In the first 6 weeks after TUVP, serum PSA was measured every week. Prostatic size was measured by transrectal ultrasonography before and again at 6 weeks after TUVP.
The mean serum PSA concentration was significantly higher at 1 and 24 h after TUVP (P<0.001) than before. The PSA level returned to less than the value before TUVP at 2, 3 and 4 weeks afterwards in eight (32%), 13 (52%) and 20 (80%) patients, respectively; five (20%) patients reached the baseline value 6 weeks after TUVP. The mean reduction in prostatic volume 6 weeks after TUVP was 42% and the reduction in tissue volume was significantly correlated with the decrease in serum PSA concentration at 6 weeks (P<0.05).
TUVP increases serum PSA levels, the transient elevation persisting for up to 6 weeks but then declining to a stable, low PSA concentration. Therefore, it is important to wait at least 6 weeks to obtain an accurate and meaningful serum PSA level after TUVP.
评估经尿道前列腺电汽化术（TUVP）对血清前列腺特异性抗原（PSA）浓度的影响。
25名有前列腺增生症状的男性（平均年龄61.7岁）接受了TUVP。在进行任何前列腺操作前测定血清PSA水平，并在TUVP后1小时和24小时再次测定。在TUVP后的前6周，每周测量血清PSA。在TUVP前及术后6周通过经直肠超声测量前列腺大小。
TUVP后1小时和24小时的平均血清PSA浓度显著高于术前（P<0.001）。术后2周、3周和4周，分别有8名（32%）、13名（52%）和20名（80%）患者的PSA水平降至低于TUVP前的值；5名（20%）患者在TUVP后6周达到基线值。TUVP后6周前列腺体积平均减少42%，组织体积的减少与6周时血清PSA浓度的降低显著相关（P<0.05）。
TUVP会使血清PSA水平升高，这种短暂升高可持续长达6周，但随后会降至稳定的低PSA浓度。因此，在TUVP后至少等待6周以获得准确且有意义的血清PSA水平很重要。
