Hammadeh M Y, Fowlis G A, Singh M, Philp T
Department of Urology, Whipps Cross Hospital, London, UK.
Br J Urol. 1998 May;81(5):721-5. doi: 10.1046/j.1464-410x.1998.00635.x.
To compare the efficacy, safety and durability of transurethral electrovaporization of the prostate (TUVP) with standard transurethral resection (TURP) in a prospective randomized trial.
The study included 104 consecutive men with symptomatic benign prostatic hyperplasia (BPH) admitted for surgery who were randomized to TUVP or TURP. The variables evaluated included the duration of surgery, catheterization and hospital stay, the International Prostate Symptom Score (IPSS), a quality-of-life assessment (QOL), the maximum urinary flow rate (Qmax) and the postvoid residual urine volume (PVR).
Both groups showed a comparable significant and maintained decline in the mean IPSS, from 26.5 to 4.4 (TUVP) and from 26.6 to 5.9 (TURP), and increase in mean Qmax, from 8.6 to 20.8 mL/s [corrected] (TUVP) and 8.6 to 22.8 mL/s (TURP) after 1 year. However, there were significant differences in the mean duration of catheterization (TUVP 20.9 h, TURP 46.6 h, P<0.001), hospital stay (TUVP 2.2 day, TURP 3.1 days, P<0.001), and the duration and volume of post-operative irrigation (TUVP none, TURP 18.1 h with 17.5 L of saline). Two patients in each group developed urethral strictures (4%) and two patients in each group required re-operation for residual adenoma (4%); two patients undergoing TURP had a bladder neck stricture (4%).
The results suggest that TUVP is as effective as standard TURP in the treatment of moderate-sized BPH. TUVP offers the advantage of using established instruments, has excellent peri-operative haemostasis and requires a shorter hospital stay.
在一项前瞻性随机试验中比较经尿道前列腺电汽化术(TUVP)与标准经尿道前列腺切除术(TURP)的疗效、安全性及耐用性。
该研究纳入了104例因症状性良性前列腺增生(BPH)入院接受手术的连续男性患者,随机分为TUVP组或TURP组。评估的变量包括手术时间、导尿时间及住院时间、国际前列腺症状评分(IPSS)、生活质量评估(QOL)、最大尿流率(Qmax)及排尿后残余尿量(PVR)。
两组患者的平均IPSS均有显著且持续的下降,1年后TUVP组从26.5降至4.4,TURP组从26.6降至5.9;平均Qmax均有升高,TUVP组从8.6升至20.8 mL/s[校正后],TURP组从8.6升至22.8 mL/s。然而,两组在平均导尿时间(TUVP组20.9小时,TURP组46.6小时,P<0.001)、住院时间(TUVP组2.2天,TURP组3.1天,P<0.001)以及术后冲洗时间和冲洗量(TUVP组无需冲洗,TURP组冲洗18.1小时,使用17.5升生理盐水)方面存在显著差异。每组各有2例患者发生尿道狭窄(4%),每组各有2例患者因残留腺瘤需要再次手术(4%);2例行TURP的患者出现膀胱颈狭窄(4%)。
结果表明,TUVP在治疗中度BPH方面与标准TURP同样有效。TUVP具有使用现有器械的优势,术中止血效果良好,且住院时间较短。