Santoro G, Romeo C, Impellizzeri P, Arco A, Rizzo G, Gentile C
Department of Biomorphology, University of Messina, Italy.
BJU Int. 1999 May;83(7):828-32. doi: 10.1046/j.1464-410x.1999.00023.x.
To verify if changes in the lamina propria and its components, reported in adults with varicocele, are already present in adolescents with idiopathic varicocele, using a morphometric and ultrastructural study.
Twenty testicular biopsies from adolescents (mean age 15.6 years) were obtained during surgery for left idiopathic varicocele; five testicular biopsies from adolescents (mean age 16 years) undergoing surgery for hydrocele or inguinal hernia were used as controls. Biopsy specimens were processed for light and transmission electron microscopy; the sections were evaluated morphometrically using computerized image analysis.
Morphometric and ultrastructural examination of the testes with varicocele showed an increased thickness in the lamina propria, caused principally by an increase in the extracellular matrix components, and deep invaginations towards the germinal epithelium.
There is detectable damage of the lamina propria in adolescents affected by left idiopathic varicocele, although not as well developed or as severe as in adults.
通过形态计量学和超微结构研究，验证精索静脉曲张成年患者中所报道的固有层及其成分的变化在特发性精索静脉曲张青少年患者中是否已经存在。
从因左侧特发性精索静脉曲张接受手术的青少年（平均年龄15.6岁）中获取20份睾丸活检标本；将5份因鞘膜积液或腹股沟疝接受手术的青少年（平均年龄16岁）的睾丸活检标本用作对照。活检标本进行光镜和透射电镜处理；使用计算机图像分析对切片进行形态计量学评估。
精索静脉曲张睾丸的形态计量学和超微结构检查显示固有层厚度增加，主要是由细胞外基质成分增加所致，并且向生精上皮有深的内陷。
受左侧特发性精索静脉曲张影响的青少年存在可检测到的固有层损伤，尽管其程度不如成年人那样严重或充分发展。
