Malochet-Grivois C, Roussakis C, Robillard N, Biard J F, Riou D, Débitus C, Verbist J F
Substances Marines à Activités Biologiques, faculté de Pharmacie, Nantes, France.
Anticancer Drug Des. 1992 Dec;7(6):493-502.
The antiproliferative activity of two nitrogenous labdane cytotoxic substances from Lissoclinum voeltzkowi Michaelson (Urochordata), dichlorolissoclimide (P2) and chlorolissoclimide (P1), was studied in vitro on a continuous human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. This antiproliferative effect resulted from a blockade of G1 phase cells. Mortality occurred, regardless of the degree of cell ploidy, with cell transition to an out-of-cycle situation characteristic of a G1D terminal maturation state.
对采自米氏柄海鞘（尾索动物）的两种含氮半日花烷型细胞毒性物质——二氯海鞘素（P2）和氯海鞘素（P1）的抗增殖活性，在细胞周期水平上对人非小细胞支气管肺癌连续细胞系（NSCLC-N6）进行了体外研究。这种抗增殖效应源于对G1期细胞的阻滞。无论细胞倍体程度如何，都会出现细胞死亡，细胞转变为具有G1D终末成熟状态特征的周期外状态。
