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Effects in vitro of sulfated polysaccharide from Schizymenia dubyi (Rhodophyta, Gigartinales) on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).

作者信息

Bourgougnon N, Roussakis C, Kornprobst J M, Lahaye M

机构信息

ISOMer, Groupe SMAB, Faculté de Pharmacie, Nantes, France.

出版信息

Cancer Lett. 1994 Sep 30;85(1):87-92. doi: 10.1016/0304-3835(94)90243-7.

DOI:10.1016/0304-3835(94)90243-7
PMID:7923107
Abstract

An unusual sulfated heteropolysaccharide containing uronic acids, previously isolated from the red alga Schizymenia dubyi, was studied in vitro for its effect on asynchronous cells of a human non-small-cell-bronchopulmonary carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the G1 phase of the cell cycle, and kinetic studies in pretreated cells showed that this growth arrest was irreversible. These events are related to a terminal maturation induction.

摘要

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