Wise P M, Smith M J, Dubal D B, Wilson M E, Krajnak K M, Rosewell K L
Department of Physiology, College of Medicine, University of Kentucky, Lexington 40536-0298, USA.
Endocr Rev. 1999 Jun;20(3):243-8. doi: 10.1210/edrv.20.3.0364.
In summary, the evidence that both the ovary and the brain are key pacemakers in the menopause is compelling. Our appreciation that estrogens are important neurotrophic and neuroprotective factors has grown rapidly. Future studies will allow us to better understand the ensemble of factors that interact to maintain regular reproductive cyclicity and how this precise dynamic balance changes with age. Furthermore, understanding how estrogen exerts trophic and protective actions should lead to its use as an important therapeutic agent in the maintenance of normal neural function during aging and after injury.
总之，卵巢和大脑都是更年期关键起搏器的证据令人信服。我们对雌激素是重要的神经营养和神经保护因子的认识迅速提高。未来的研究将使我们能够更好地理解相互作用以维持正常生殖周期的一系列因素，以及这种精确的动态平衡如何随年龄变化。此外，了解雌激素如何发挥营养和保护作用，应会促使其被用作在衰老过程和损伤后维持正常神经功能的重要治疗药物。
