Laerum O D
Arch Toxicol. 1976 Dec 17;36(3-4):247-54. doi: 10.1007/BF00340532.
The induction of tumours by chemical carcinogens depends not only on the chemical structure of the substance but also on biological properties of the target cell population, such as enzyme patterns, DNA repair mechanisms and the proliferative state of the cells. Interference with any of these processes can theoretically affect the tumour yield, as can variations due to biological rhythms. A series of investigations of circadian and circannual rhythms in the hairless mouse epidermis (hr/hr) is reviewed. DNA synthesis as well as the mitotic rate undergo great variations in the course of a 24-h period. The respiration and glycolysis in this epidermis undergo strong circannual variations. Evidence that the eventual tumour development after methylcholanthrene application to the skin is modified by circadian variations in DNA synthesis is presented and discussed in relation to pertinent data from other cell systems.
化学致癌物诱发肿瘤不仅取决于物质的化学结构，还取决于靶细胞群体的生物学特性，如酶谱、DNA修复机制以及细胞的增殖状态。理论上，干扰这些过程中的任何一个都可能影响肿瘤发生率，生物节律引起的变化也会如此。本文综述了对无毛小鼠表皮（hr/hr）昼夜节律和年节律的一系列研究。DNA合成以及有丝分裂率在24小时内会发生很大变化。该表皮中的呼吸作用和糖酵解存在强烈的年节律变化。本文给出了在皮肤涂抹甲基胆蒽后最终肿瘤发生情况会因DNA合成的昼夜变化而改变的证据，并结合来自其他细胞系统的相关数据进行了讨论。
