Iversen U, Iversen O H
Cancer Res. 1976 Apr;36(4):1238-41.
The sensitivity of hairless mice to cutaneous chemical carcinogenesis has been compared with that of normal mice of the same strain with hair. A single application of 125 mug methylcholanthrene in benzene was given to 48 hairless male mice (hr/hr Oslo strain) and to 96 male mice of the same strain with hair. Among hairless mice there were 94% papilloma-bearing animals with a total of 5.9 tumors per animal after 18 months of observation, compared to 22% papilloma-bearing animals with an average of 0.3 tumors per animal among the mice with hair. The hairless mice included 31% carcinoma-bearing and 23% sarcoma-bearing animals, whereas only 1% of the mice with hair were carcinoma bearing and 3% were sarcoma bearing. Hairless mice of the hr/hr Oslo strain are thus not refractory to chemical carcinogenesis, but under the experimental conditions used in this study they are significantly more sensitive than are mice from the same strain with hair. Giovanella et al. reported almost opposite results in 1970 and came to the general conclusion that hairless mice are refractory to chemical carcinogenesis due to lack of hair follicles. Since hairless mice always have some hair follicles and rudimentary pilosebaceous appendages, comparisons between chemical carcinogenesis in hairless mice and mice with hair can neither strengthen nor weaken any theory about the hair follicle origin of epidermoid carcinomas of mouse skin.
已将无毛小鼠对皮肤化学致癌作用的敏感性与同一品系有毛正常小鼠的敏感性进行了比较。给48只无毛雄性小鼠（hr/hr奥斯陆品系）和96只同一品系的有毛雄性小鼠单次涂抹125微克苯并[a]芘。在观察18个月后，无毛小鼠中有94%的动物发生乳头状瘤，每只动物平均有5.9个肿瘤，相比之下，有毛小鼠中有22%的动物发生乳头状瘤，每只动物平均有0.3个肿瘤。无毛小鼠中有31%的动物发生癌，23%的动物发生肉瘤，而有毛小鼠中只有1%的动物发生癌，3%的动物发生肉瘤。因此，hr/hr奥斯陆品系的无毛小鼠对化学致癌作用并非不敏感，但在本研究使用的实验条件下，它们比同一品系的有毛小鼠明显更敏感。乔瓦内拉等人在1970年报告了几乎相反的结果，并得出一般结论称，无毛小鼠由于缺乏毛囊而对化学致癌作用不敏感。由于无毛小鼠总是有一些毛囊和基本的毛皮脂腺附属器，因此无毛小鼠与有毛小鼠化学致癌作用之间的比较既不能支持也不能削弱任何关于小鼠皮肤表皮样癌毛囊起源的理论。
