Economides F, Bruley-Rosset M
Biomedicine. 1976 Dec 30;25(10):390-5.
This work presents data concerning the effect of tumor excision accompanied or not by the removal of the regional lymph node (RLN) on the survival time of mice bearing the EAkR lymphosarcoma or the B16 melanoma. The operations were performed at various times to study this effect in relation to tumor volume. Early tumorectomy, on day 6 for the EAkR lymphosarcoma, on day 10 for the B16 melanoma, prolonged significantly the survival time. The additional removal of the RLN abolished this beneficial effect. In the case of the EAkR lymphosarcoma, a beneficial effect on the survival time was in contrast observed after a total excision of the tumor accompanied by RLN removal performed on day 8. The two surgical procedures were ineffective in increasing the survival time when they were applied after the 8th day for the EAkR lymphosarcoma and after the 10th day for the B16 melanoma. These results suggest that the preservation of the RLN may be favorable for the host at least at an early stage of the tumor growth.
这项研究呈现了有关切除肿瘤时是否同时切除区域淋巴结（RLN）对携带EAkR淋巴肉瘤或B16黑色素瘤的小鼠存活时间影响的数据。在不同时间进行手术，以研究这种影响与肿瘤体积的关系。早期肿瘤切除术，对于EAkR淋巴肉瘤在第6天进行，对于B16黑色素瘤在第10天进行，显著延长了存活时间。额外切除RLN消除了这种有益效果。对于EAkR淋巴肉瘤，在第8天进行肿瘤全切除并同时切除RLN后，观察到对存活时间有有益影响。当在EAkR淋巴肉瘤第8天后以及B16黑色素瘤第10天后应用这两种手术时，它们在延长存活时间方面无效。这些结果表明，至少在肿瘤生长的早期阶段，保留RLN可能对宿主有利。
