Economides F, Bruley-Rosset M
Recent Results Cancer Res. 1977(62):2-7. doi: 10.1007/978-3-642-81174-6_1.
This work presents data concerning the effect of tumor excision accompanied or not by the removal of the regional lymph node (RLN) on the survival time of mice bearing the EAkR lymphosarcoma or the B16 melanoma. The operations were performed at various times to study this effect in relation to tumor size. Early tumorectomy, on day 6 for the EAkR lymphosarcoma, on day 10 for the B16 melanoma, significantly prolonged the survival time. The additional removal of the RLN abolished this beneficial effect. In the case of the EAkR lymphosarcoma. a beneficial effect on the survival time was, in contrast, observed after total excision of the tumor accompanied by RLN removal performed on day 8. The two surgical procedures were ineffective in increasing the survival time when they were applied after the 8th day for the EAkR lymphosarcoma and after the 10th day for the B16 melanoma. These results suggest that the preservation of the RLN may be favorable for the host, at least at an early stage of the tumor growth.
这项研究给出了有关切除肿瘤（伴或不伴区域淋巴结（RLN）切除）对携带EAkR淋巴肉瘤或B16黑色素瘤的小鼠存活时间影响的数据。在不同时间进行手术，以研究这种影响与肿瘤大小的关系。早期肿瘤切除术，对于EAkR淋巴肉瘤在第6天进行，对于B16黑色素瘤在第10天进行，显著延长了存活时间。额外切除RLN消除了这种有益效果。然而，对于EAkR淋巴肉瘤，在第8天进行肿瘤全切并伴RLN切除后，观察到对存活时间有有益影响。当在EAkR淋巴肉瘤第8天后以及B16黑色素瘤第10天后应用这两种手术方法时，它们在延长存活时间方面无效。这些结果表明，保留RLN可能对宿主有利，至少在肿瘤生长的早期阶段是这样。
