Economides F, Bruley-Rosset M, Mathé G
Biomedicine. 1976 Dec 30;25(10):372-5.
A combined treatment modality incorporating surgery plus BCG immunotherapy was administered to (DBA/2 X C57B/6) F1 mice grafted with EAkR lymphosarcoma. 30% of mice survived free of disease when BCG was injected intravenously two days after operation consisting of tumorectomy plus excision of the regional lymph node performed on the 8th day after tumor inoculation. Similar results were obtained when BCG was injected subcutaneously 6 days before surgery. Pre-operative intravenous and post-operative subcutanous BCG administration failed to cure the animals just as BCG or surgery alone.
对移植了EAkR淋巴肉瘤的（DBA/2×C57B/6）F1小鼠采用手术加卡介苗免疫疗法的联合治疗模式。在肿瘤接种后第8天进行肿瘤切除加区域淋巴结切除手术后两天静脉注射卡介苗，30%的小鼠存活且无疾病。在手术前6天皮下注射卡介苗也获得了类似结果。术前静脉注射和术后皮下注射卡介苗均未能治愈动物，就如同单独使用卡介苗或手术一样。
